J Clin Microbiol. 2011 Jan;49(1):385-8. Epub 2010 Oct 27.

Mixed-strain Mycobacterium tuberculosis infections among patients dying in a hospital in KwaZulu-Natal, South Africa.

Cohen T, Wilson D, Wallengren K, Samuel EY, Murray M.

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Division of Global Health Equity, Brigham and Women's Hospital, Boston, MA 02115, USA. tcohen@hsph.harvard.edu

Abstract

We performed spoligotyping and 24-locus mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) typing on M. tuberculosis culture-positive biopsy specimens collected from adults dying in a hospital in KwaZulu-Natal. Of 56 culture-positive samples genotyped, we detected mixed strains in five (9%) and clonal heterogeneity in an additional four (7%).

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