Format

Send to:

Choose Destination
See comment in PubMed Commons below
Eur Biophys J. 2011 Feb;40(2):153-63. doi: 10.1007/s00249-010-0635-6. Epub 2010 Oct 27.

The effects of cholesterol and β-sitosterol on the structure of saturated diacylphosphatidylcholine bilayers.

Author information

  • 1Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University, 83232 Bratislava, Slovakia. gallova@fpharm.uniba.sk

Abstract

The structures of DMPC and DPPC bilayers in unilamellar liposomes, in the presence of 33.3 mol% cholesterol or the plant sterol β-sitosterol, have been studied by small-angle neutron scattering. The bilayer thickness d(L) increases in a similar way for both sterols. The repeat distance in multilamellar liposomes, as determined by small-angle X-ray diffraction, is larger in the presence of β-sitosterol than in the presence of cholesterol. We observe that each sterol modifies the interlamellar water layer differently, cholesterol reducing its thickness more efficiently than β-sitosterol, and conclude that cholesterol suppresses bilayer undulations more effectively than β-sitosterol.

PMID:
20978886
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk