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J Infect Dis. 2010 Dec 1;202(11):1713-21. doi: 10.1086/657142. Epub 2010 Oct 26.

Molecular analysis of household transmission of Giardia lamblia in a region of high endemicity in Peru.

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  • 1Department of Veterinary Science and Microbiology, University of Arizona, Tucson, USA.

Abstract

BACKGROUND:

Giardia lamblia is ubiquitous in multiple communities of nonindustrialized nations. Genotypes A1, A2, and B (Nash groups 1, 2, and 3, respectively) are found in humans, whereas genotypes C and D are typically found in dogs. However, genotypes A and B have occasionally been identified in dogs.

METHODS:

Fecal Giardia isolates from 22 families and their dogs, living in Pampas de San Juan, were collected over 7 weeks in 2002 and 6 weeks in 2003. Samples were genotyped, followed by sequencing and haplotyping of many of these isolates by using loci on chromosomes 3 and 5.

RESULTS:

Human infections were all caused by isolates of genotypes A2 and B. Human coinfections with genotypes A2 and B were common, and the reassortment pattern of different subtypes of A2 isolates supports prior observations that suggested recombination among genotype A2 isolates. All dogs had genotypes C and/or D, with one exception of a dog with a mixed B/D genotype infection.

CONCLUSIONS:

In a region of high endemicity where infected dogs and humans constantly commingle, different genotypes of Giardia are almost always found in dogs and humans, suggesting that zoonotic transmission is very uncommon.

PMID:
20977340
[PubMed - indexed for MEDLINE]
PMCID:
PMC2974043
Free PMC Article

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