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PLoS Pathog. 2010 Oct 14;6(10):e1001033. doi: 10.1371/journal.ppat.1001033.

Host genetics and HIV-1: the final phase?

Author information

  • 1Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, United States of America. jacques.fellay@duke.edu

Abstract

This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral load or disease progression. Results from other studies that used various large-scale approaches (siRNA screens, transcriptome or proteome analysis, comparative genomics) have also shed new light on retroviral pathogenesis. However, most of the inter-individual variability in response to HIV-1 infection remains to be explained: genome resequencing and systems biology approaches are now required to progress toward a better understanding of the complex interactions between HIV-1 and its human host.

PMID:
20976252
[PubMed - indexed for MEDLINE]
PMCID:
PMC2954832
Free PMC Article

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