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Onkologie. 2010;33(11):613-5. doi: 10.1159/000321126. Epub 2010 Oct 15.

Giant basal cell carcinoma of the breast mimicking paget's disease: complete remission after photodynamic therapy.

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  • 1Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein, Kiel, Germany.



Basal cell carcinoma (BCC) in the nipple area is extremely rare and can be mistaken for Paget's disease.


A 47-year-old woman complained of a slowly growing, scaly erythematous plaque around her right nipple which had developed over several years. Paget's disease of the breast was suspected. Biopsies revealed a superficial BCC. The maximum tumor thickness was measured as 1 mm. Considering the superficial character of the tumor, photodynamic therapy (PDT) as a non-invasive approach was performed. Complete remission (CR) with an excellent cosmetic result was achieved after 4 PDT sessions. In the follow-up, CR with no signs of a local recurrence was evident after more than 24 months.


In similar superficial cases of BCCs, non-invasive procedures such as PDT can be discussed as an alternative option to radical surgery or radiotherapy, with an excellent aesthetic outcome in carefully selected cases.

Copyright © 2010 S. Karger AG, Basel.

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