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Fetal Diagn Ther. 2010;28(3):167-74. doi: 10.1159/000318345. Epub 2010 Oct 26.

Assessment of left ventricular pre-ejection period in the fetus using simultaneous magnetocardiography and echocardiography.

Author information

  • 1Department of Medical Physics, University of Wisconsin, Madison, USA.

Abstract

INTRODUCTION:

Fetal magnetocardiography (fMCG) is a promising new technique for assessing fetal rhythm; however, no prior studies have utilized fMCG to evaluate human fetal electromechanical physiology. Pre-ejection period (PEP) is an important measure of the electromechanical activation of the heart, and is altered by disease states and arrhythmias.

MATERIALS AND METHODS:

A novel technique was used to assess fetal PEP and its relationship to other fetal systolic time intervals, RR interval, and gestational age (GA). 25 normal human fetuses between 19 and 38 weeks' gestation were studied using simultaneous pulsed Doppler ultrasound and fMCG. Correlations among PEP, ejection time, QRS width and RR interval were assessed using linear regression.

RESULTS:

Across all subjects, PEP was found to correlate with GA (R = 0.57, p < 0.0001), QRS width (R = 0.35, p = 0.026), and RR interval (R = 0.37, p = 0.018). In individual sessions, PEP negatively correlated beat-to-beat with the preceding RR interval.

CONCLUSION:

PEP exhibits developmental trends that provide a better understanding of the normal development of the human fetal heart.

Copyright © 2010 S. Karger AG, Basel.

PMID:
20975278
[PubMed - indexed for MEDLINE]
PMCID:
PMC2992646
Free PMC Article

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