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Antimicrob Agents Chemother. 2011 Jan;55(1):426-8. doi: 10.1128/AAC.01257-10. Epub 2010 Oct 25.

Effect of antibiotic treatment on bacteriophage production by a cystic fibrosis epidemic strain of Pseudomonas aeruginosa.

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  • 1NIHR Biomedical Research Centre in Microbial Disease, Royal Liverpool University Hospital, Liverpool, United Kingdom.


Phage production in response to antibiotics varied among four isolates of a Pseudomonas aeruginosa cystic fibrosis (CF) epidemic strain. Whereas ciprofloxacin induced higher levels of phage production, other CF-relevant antibiotics led to reduced production. We detected free phages directly in CF patient sputum samples by both plaque (40% positive) and PCR (76% positive) assays. Our observations suggest that the choice of antibiotics could influence the number of free phages within the CF lung environment.

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