Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Hum Immunol. 2011 Feb;72(2):107-14. doi: 10.1016/j.humimm.2010.10.012. Epub 2010 Nov 4.

Gene profile analysis of CD8(+) ILT3-Fc induced T suppressor cells.

Author information

  • 1Department of Pathology and Cell Biology, Columbia University, New York, New York, USA.

Abstract

Gene profile analysis of ILT3-Fc-induced Ts revealed a significant upregulation of Zink finger proteins, most of which act as transcriptional repressors. Included among these repressors is BCL6, which was shown to play a critical role in the differentiation of ILT3-Fc-induced T suppressor (Ts) cells. Genes implicated in cell cycle progression were downregulated. Genes encoding numerous inflammatory cytokines and chemokines were also downregulated. In contrast, antiapoptotic genes, as well as members of the WNT and transforming growth factor-β pathways, were upregulated. This study elucidates certain important aspects of Ts differentiation and function.

Copyright © 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

PMID:
20974207
[PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk