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Hum Immunol. 2011 Feb;72(2):107-14. doi: 10.1016/j.humimm.2010.10.012. Epub 2010 Nov 4.

Gene profile analysis of CD8(+) ILT3-Fc induced T suppressor cells.

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  • 1Department of Pathology and Cell Biology, Columbia University, New York, New York, USA.


Gene profile analysis of ILT3-Fc-induced Ts revealed a significant upregulation of Zink finger proteins, most of which act as transcriptional repressors. Included among these repressors is BCL6, which was shown to play a critical role in the differentiation of ILT3-Fc-induced T suppressor (Ts) cells. Genes implicated in cell cycle progression were downregulated. Genes encoding numerous inflammatory cytokines and chemokines were also downregulated. In contrast, antiapoptotic genes, as well as members of the WNT and transforming growth factor-β pathways, were upregulated. This study elucidates certain important aspects of Ts differentiation and function.

Copyright © 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

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