Anesth Prog. 1990 Sep-Oct;37(5):223-9.

Utilization and mechanism of action of tricyclic antidepressants in the treatment of chronic facial pain: a review of the literature.

Source

University of Texas Health Science Center, Houston.

Abstract

Tricyclic antidepressants show promise in the treatment of chronic facial pain. The antinociceptive activity of this class of drugs appears to be independent of any antidepressant effects. An hypothesis is proposed that tricyclics antidepressants activate a descending serotonergic (5-HT1) antinociceptive pathway which in turn influences endogenous opioids. This antinociceptive pathway appears to utilize an endogenous pain modulation system. Future studies may demonstrate the operative mechanisms of action and open understanding as to etiologic factors.

PMID:: 2096745; [PubMed - indexed for MEDLINE]
PMCID:: PMC2148604

Free PMC Article

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Education

New England Research Institutes Inc.

Medical

Pain - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Review The use of tricyclic antidepressants for the control of chronic orofacial pain. [Cranio. 1997]
Review The use of tricyclic antidepressants for the control of chronic orofacial pain.
Pettengill CA, Reisner-Keller L. Cranio. 1997 Jan; 15(1):53-6.
Review The use of tricyclic antidepressants in the treatment of temporomandibular joint disorders: systematic review of the literature of the last 20 years. [Med Oral Patol Oral Cir Bucal....]
Review The use of tricyclic antidepressants in the treatment of temporomandibular joint disorders: systematic review of the literature of the last 20 years.
Cascos-Romero J, Vázquez-Delgado E, Vázquez-Rodríguez E, Gay-Escoda C. Med Oral Patol Oral Cir Bucal. 2009 Jan 1; 14(1):E3-7. Epub 2009 Jan 1.
Tricyclic antidepressant drugs: pharmacologic implications in the treatment of chronic orofacial pain. [Compendium. 1987]
Tricyclic antidepressant drugs: pharmacologic implications in the treatment of chronic orofacial pain.
Hersh EV. Compendium. 1987 Oct; 8(9):688, 690, 692-4.
Clinical pharmacology of chronic orofacial pain medications. [Compendium. 1989]
Clinical pharmacology of chronic orofacial pain medications.
Paul RE, Hersh EV. Compendium. 1989 Sep; 10(9):492, 494-8.
Review A critical review of the use of botulinum toxin in orofacial pain disorders. [Dent Clin North Am. 2007]
Review A critical review of the use of botulinum toxin in orofacial pain disorders.
Clark GT, Stiles A, Lockerman LZ, Gross SG. Dent Clin North Am. 2007 Jan; 51(1):245-61, ix.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC

Recent activity

Clear Turn Off Turn On

Utilization and mechanism of action of tricyclic antidepressants in the treatmen...
Utilization and mechanism of action of tricyclic antidepressants in the treatment of chronic facial pain: a review of the literature.
Anesth Prog. 1990 Sep-Oct ;37(5):223-9.

PubMed
Towards a unifying, systems biology understanding of large-scale cellular death ...
Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples.
Arch Toxicol. 2010 Nov ;84(11):825-89. Epub 2010 Aug 17 .

PubMed
Risk management in clinical practice. Part 7. Dento-legal aspects of orthodontic...
Risk management in clinical practice. Part 7. Dento-legal aspects of orthodontic practice.
Br Dent J. 2010 Oct 23 ;209(8):381-90.

PubMed
Genome-wide association study of anthropometric traits and evidence of interacti...
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
Obesity (Silver Spring). 2011 May ;19(5):1019-27. Epub 2010 Oct 21 .

PubMed
Analysis of outcomes of microinvasive adenocarcinoma of the uterine cervix by tr...
Analysis of outcomes of microinvasive adenocarcinoma of the uterine cervix by treatment type.
Obstet Gynecol. 2010 Nov ;116(5):1150-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: