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Acta Pathol Jpn. 1990 Dec;40(12):927-34.

Aggressive angiomyxoma of the vulva. Report of a case.

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  • 1Division of Pathology, Shikoku Cancer Center Hospital, Matsuyama, Japan.


A case of aggressive angiomyxoma of the vulva is reported. A 43-year-old woman presented initially in 1987 with a left vulvar mass which clinically was thought to be a lipoma or a Bartholin gland cyst. Local excision was performed after a 27-month follow-up without any change in size. The resected tumor measured 2.7 x 2.0 x 2.0 cm and had a smooth, glistening and myxoid cut surface. Histologically, the lesion was composed of spindle-shaped or stellate neoplastic cells, which were loosely textured in the fibromyxoid matrix, and a prominent vascular component characterized by randomly distributed vascular channels of variable caliber. Immunohistochemically, the tumor cells were positive for vimentin, but not for desmin and myosin. The fine structure of the neoplastic cells was compatible with that of fibroblasts rather than myofibroblasts. These findings suggest the fibroblastic differentiation of this tumor. The patient is currently well with no evidence of recurrence, 7 months after excision of the tumor.

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