Mol Oncol. 2010 Dec;4(6):529-38. Epub 2010 Sep 25.

MALDI imaging mass spectrometry--painting molecular pictures.

Source

Mass Spectrometry Research Center, Department of Biochemistry, Vanderbilt University, Nashville, TN, USA.

Abstract

MALDI Imaging Mass Spectrometry is a molecular analytical technology capable of simultaneously measuring multiple analytes directly from intact tissue sections. Histological features within the sample can be correlated with molecular species without the need for target-specific reagents such as antibodies. Several studies have demonstrated the strength of the technology for uncovering new markers that correlate with disease severity as well as prognosis and therapeutic response. This review describes technological aspects of imaging mass spectrometry together with applications in cancer research.

PMID:: 20965799; [PubMed - indexed for MEDLINE]
PMCID:: PMC2981679

Free PMC Article

Images from this publication.See all images (4) Free text

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Laser desorption-ionization of lipid transfers: tissue mass spectrometry imaging without MALDI matrix. [Anal Chem. 2010]
Laser desorption-ionization of lipid transfers: tissue mass spectrometry imaging without MALDI matrix.
Vidová V, Novák P, Strohalm M, Pól J, Havlícek V, Volný M. Anal Chem. 2010 Jun 15; 82(12):4994-7.
Review Imaging of intact tissue sections: moving beyond the microscope. [J Biol Chem. 2011]
Review Imaging of intact tissue sections: moving beyond the microscope.
Seeley EH, Schwamborn K, Caprioli RM. J Biol Chem. 2011 Jul 22; 286(29):25459-66. Epub 2011 Jun 1.
Molecular imaging by mass spectrometry--looking beyond classical histology. [Nat Rev Cancer. 2010]
Molecular imaging by mass spectrometry--looking beyond classical histology.
Schwamborn K, Caprioli RM. Nat Rev Cancer. 2010 Sep; 10(9):639-46. Epub 2010 Aug 19.
Review MALDI mass spectrometry imaging in oncology (Review). [Mol Med Report. 2011]
Review MALDI mass spectrometry imaging in oncology (Review).
Gemoll T, Roblick UJ, Habermann JK. Mol Med Report. 2011 Nov-Dec; 4(6):1045-51. Epub 2011 Aug 22.
Review MALDI mass spectrometry imaging, from its origins up to today: the state of the art. [Comb Chem High Throughput Scre...]
Review MALDI mass spectrometry imaging, from its origins up to today: the state of the art.
Francese S, Dani FR, Traldi P, Mastrobuoni G, Pieraccini G, Moneti G. Comb Chem High Throughput Screen. 2009 Feb; 12(2):156-74.

See reviews... See all...

Cited by 1 PubMed Central article

Detailed Structural Analysis of Lipids Directly on Tissue Specimens Using a MALDI-SpiralTOF-Reflectron TOF Mass Spectrometer. [PLoS One. 2012]
Detailed Structural Analysis of Lipids Directly on Tissue Specimens Using a MALDI-SpiralTOF-Reflectron TOF Mass Spectrometer.
Shimma S, Kubo A, Satoh T, Toyoda M. PLoS One. 2012; 7(5):e37107. Epub 2012 May 18.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

MALDI imaging mass spectrometry--painting molecular pictures.
MALDI imaging mass spectrometry--painting molecular pictures.
Mol Oncol. 2010 Dec ;4(6):529-38. Epub 2010 Sep 25 .

PubMed
[The problem of communication in children with hearing disorders in relation to ...
[The problem of communication in children with hearing disorders in relation to general aspects of the development of communicative behavior. A review].
Z Kinder Jugendpsychiatr. 1990 Dec ;18(4):224-30.

PubMed
Photochemical and phototoxic properties of ethyl 1,4-dihydro-8-nitro-4-oxoquinol...
Photochemical and phototoxic properties of ethyl 1,4-dihydro-8-nitro-4-oxoquinoline-3-carboxylate, a new quinoline derivative.
J Photochem Photobiol B. 2011 Jan 10 ;102(1):77-91. Epub 2010 Oct 1 .

PubMed
Targeting stem cell niches and trafficking for cardiovascular therapy.
Targeting stem cell niches and trafficking for cardiovascular therapy.
Pharmacol Ther. 2011 Jan ;129(1):62-81. Epub 2010 Oct 20 .

PubMed
A systematic review of insomnia and complementary medicine.
A systematic review of insomnia and complementary medicine.
Sleep Med Rev. 2011 Apr ;15(2):99-106. Epub 2010 Jun 8 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: