Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neuroimage. 2011 Feb 1;54(3):1887-95. doi: 10.1016/j.neuroimage.2010.10.027. Epub 2010 Oct 18.

β-Amyloid affects frontal and posterior brain networks in normal aging.

Author information

  • 1Helen Wills Neuroscience Institute, University of California-Berkeley, Berkeley, CA 94720-3190, USA. hwameeoh@berkeley.edu

Abstract

Although deposition of β-amyloid (Aβ), a pathological hallmark of Alzheimer's disease (AD), has also been reported in cognitively intact older people, its influence on brain structure and cognition during normal aging remains controversial. Using PET imaging with the radiotracer Pittsburgh compound B (PIB), structural MRI, and cognitive measures, we examined the relationships between Aβ deposition, gray matter volume, and cognition in older people without AD. Fifty-two healthy older participants underwent PIB-PET and structural MRI scanning and detailed neuropsychological tests. Results from the whole-brain voxel-based morphometry (VBM) analysis revealed that gray matter volume in the left inferior frontal cortex was negatively associated with amyloid deposition across all participants whereas reduced gray matter volume was shown in the posterior cingulate among older people with high amyloid deposition. When gray matter density measures extracted from these two regions were related to other brain regions by applying a structural covariance analysis, distinctive frontal and posterior brain networks were seen. Gray matter volume in these networks in relation to cognition, however, differed such that reduced frontal network gray matter volume was associated with poorer working memory performance while no relationship was found for the posterior network. The present findings highlight structural and cognitive changes in association with the level of Aβ deposition in cognitively intact normal elderly and suggest a differential role of Aβ-dependent gray matter loss in the frontal and posterior networks in cognition during normal aging.

Copyright © 2010 Elsevier Inc. All rights reserved.

PMID:
20965254
[PubMed - indexed for MEDLINE]
PMCID:
PMC3038633
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk