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Cold Spring Harb Perspect Biol. 2010 Dec;2(12):a000752. doi: 10.1101/cshperspect.a000752. Epub 2010 Oct 20.

RNA processing and export.

Author information

  • 1Department for Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Abstract

Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression.

PMID:
20961978
[PubMed - indexed for MEDLINE]
PMCID:
PMC2982171
Free PMC Article

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