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Br J Cancer. 2010 Nov 23;103(11):1749-54. doi: 10.1038/sj.bjc.6605956. Epub 2010 Oct 19.

Dietary acrylamide intake and risk of breast cancer in the UK women's cohort.

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  • 1Centre for Epidemiology and Biostatistics, University of Leeds, Leeds LS2 9JT, UK.



No studies to date have demonstrated a clear association with breast cancer risk and dietary exposure to acrylamide.


A 217-item food frequency questionnaire was used to estimate dietary acrylamide intake in 33,731 women aged 35-69 years from the UK Women's Cohort Study followed up for a median of 11 years.


In all, 1084 incident breast cancers occurred during follow-up. There was no evidence of an overall association between acrylamide intake and breast cancer (hazard ratio=1.08 per 10 μg day(-1), 95% CI: 0.98-1.18, P(trend)=0.1). There was a suggestion of a possible weak positive association between dietary acrylamide intake and premenopausal breast cancer after adjustment for potential confounders (hazard ratio=1.2, 95% CI: 1.0-1.3, P(trend)=0.008). There was no suggestion of any association for postmenopausal breast cancer (hazard ratio=1.0, 95% CI: 0.9-1.1, P(trend)=0.99).


There is no evidence of an association between dietary acrylamide intake and breast cancer. A weak association may exist with premenopausal breast cancer, but requires further investigation.

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