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    Cephalalgia. 2010 Nov;30(11):1306-28. Epub 2010 May 4.

    Sex hormone receptor gene polymorphisms and migraine: a systematic review and meta-analysis.

    Schürks M, Rist PM, Kurth T.

    Source

    Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215-1204, USA. mschuerks@rics.bwh.harvard.edu

    Abstract

    BACKGROUND:

    Data on the association between sex hormone receptor polymorphisms and migraine are conflicting.

    METHODS:

    We performed a systematic review and meta-analysis on this topic searching for studies published until August 2009. For each study, we calculated odds ratios (ORs) and 95% confidence intervals (CIs) assuming additive, dominant, and recessive genetic models. We then calculated pooled ORs and 95% CIs.

    RESULTS AND CONCLUSION:

    Among the seven genes targeted, four variants were investigated in multiple studies. Effect estimates from an additive model suggest that the ESR-1 594 G>A (pooled OR 1.37; 95% CI 1.02-1.83) and ESR-1 325 C>G (pooled OR 1.16; 95% CI 1.03-1.32) variants are associated with any migraine. This pattern does not differ between migraine with and without aura. In contrast, the ESR-1 Pvu II C>T and PGR PROGINS insert polymorphism do not appear to be associated with migraine. Results were driven by studies among Caucasians and may differ in other ethnic groups.

    PMID:
    20959426
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3055237
    Free PMC Article

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