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J Natl Cancer Inst Monogr. 2010;2010(41):162-77. doi: 10.1093/jncimonographs/lgq039.

Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast.

Collaborators (610)

Abe O, Abe R, Enomoto K, Kikuchi K, Koyama H, Masuda H, Nomura Y, Ohashi Y, Sakai K, Sugimachi K, Toi M, Tominaga T, Uchino J, Yoshida M, Haybittle JL, Leonard CF, Calais G, Geraud P, Collett V, Davies C, Delmestri A, Sayer J, Harvey VJ, Holdaway TM, Kay RG, Mason BH, Forbes JF, Wilcken N, Bauernhofer T, Dubsky P, Fesl C, Fohler H, Filipcic L, Filipits M, Fridrik M, Gnant M, Greil R, Hegenbarth K, Jakesz R, Kwasny W, Lang A, Luschin-Ebengreuth G, Marth C, Menzel C, Mlineritsch B, Samonigg H, Seifert M, Sevelda P, Singer C, Steger GG, Stöger H, Thaler J, Tschmelitsch J, Zielinski C, Canney P, Yosef HM, Focan C, Peek U, Oates GD, Powell J, Durand M, Mauriac L, Di Leo A, Dolci S, Piccart MJ, Masood MB, Parker D, Price JJ, Lindsay MA, Mackey J, Martin M, Hupperets PS, Bates T, Blamey RW, Chetty U, Ellis IO, Mallon E, Morgan DA, Patnick J, Pinder S, Jackson S, Ragaz J, Berry D, Broadwater G, Cirrincione C, Muss H, Norto L, Weiss RB, Abu-Zahra HT, Portnoj SM, Baum M, Cuzick J, Dowsett M, Houghton J, Ledermann J, Riley D, Bowdon S, Brookes C, Fernando I, Rea D, Spooner D, Mansel RE, Gordon NH, Davis HL, Lehingue Y, Romestaing P, Dubois JB, Delozier T, Griffon B, Mace Lesec'h J, Rambert P, Mustacchi G, Petruzelka L, Pribylova O, Owen JR, Harbeck N, Jänicke F, Meisner C, Schmitt M, Thomssen C, Meier P, Howell A, Swindell R, Burrett J, Clarke M, Collins R, Correa C, Cutter D, Darby S, Davies C, Davies K, Delmestri A, Elphinstone P, Evans V, Gettins L, GodwinF J, Gray R, Gregory C, Hermans D, Hicks C, James S, Kerr A, MacKinnon E, Lay M, McGale P, McHugh T, Peto R, Sayer J, Taylor C, Wang Y, Albano J, de Oliveira CF, Gervásio H, Gordilho J, Johansen H, Mouridsen HT, Gelman RS, Harris JR, Hayes D, Henderson IC, Shapiro CL, Winer E, Christiansen P, Ejlertsen B, Ewertz M, Mouridsen HT, Møller S, Overgaard M, Carstensen B, Palshof T, Trampisch HJ, Dalesio O, de Vries EG, Rodenhuis S, van Tinteren H, ComisF RL, DavidsonF NE, Gray R, Robert N, SledgeF G, Solin FJ, Tormey DC, Wood W, Cameron D, Chetty U, Forrest P, Jack W, Rossbach J, Klijn JG, Treurniet-Donker AD, van Putten WL, Costa A, Veronesi U, Viale G, Bartelink H, Bogaerts J, Bijker N, Julien JP, Legrand C, Rutgers E, Sylvester R, van de Velde CJ, van Nes JG, Cunningham MP, Huovinen R, Joensuu H, Costa A, Tinterri C, Valagussa P, Valagussa P, Goldstein LJ, Bonneterre J, Fargeot P, Fumoleau P, Kerbrat P, Luporsi E, Namer M, Eiermann W, Hilfrich J, Jonat W, Kaufmann M, KreienbergF R, Schumacher M, Bastert G, Rauschecker H, Sauer R, Sauerbrei W, Schauer A, Schumacher M, Blohmer JU, Costa SD, Eidtmann H, Gerber B, Jackisch C, Loibl S, von Minckwitz G, de Schryver A, Vakaet L, Belfiglio M, Nicolucci A, Pellegrini F, Sacco M, Valentini M, McArdle CS, Smith DC, Stallard S, Galligioni E, Lopez M, Boccardo F, Rubagotti A, Dent DM, Gudgeon CA, Hacking A, Murray E, Panieri E, Briones L, Carrasco E, Martin M, Erazo A, Medina JY, Horiguchi J, Takei H, Fentiman IS, Hayward JL, Rubens RD, Skilton D, Scheurlen H, Kaufmann M, Sohn HC, Untch M, Dafni U, Markopoulos C, Dafni U, Fountzilas G, Mavroudis D, Klefstrom P, Blomqvist C, Saarto C, Gallen M, Margreiter R, de Lafontan B, Mihura J, RochéF H, Asselain B, Salmon RJ, Vilcoq JR, Arriagada R, Hill C, Laplanche A, Lê MG, Spielmann M, A'Hern R, Barrett-Lee P, Bliss J, Ellis P, Kilburn L, Yarnold JR, Bruzzi P, Del Mastro L, Pronzato P, Sertoli MR, Venturini M, Amadori D, Benraadt J, Kooi M, van de Velde AO, van Dongen JA, Vermorken JB, Castiglione M, Cavalli F, Coates A, Collins J, Forbes J, Gelber RD, Goldhirsch A, Lindtner J, Price KN, Raina V, Rudenstam CM, Senn HJ, Bliss JM, Chilvers CE, Coombes RC, Hall E, Marty M, Buyse M, Possinger K, Schmid P, Untch M, Wallwiener D, Borovik R, Brufman G, Hayat H, Robinson E, Yaal-Hahoshen N, Bonadonna G, Camerini T, De Palo G, Di MauroF MG, Formelli F, Valagussa P, Martoni A, Pannuti F, Cocconi G, Colozza A, Camisa R, Gori S, Aogi K, Takashima S, Abe O, Ikeda T, Inokuchi K, Kikuchi K, Sawa K, Sonoo H, Korzeniowski S, Skolyszewski J, Ogawa M, Yamashita J, Christiaens R, Neven P, Paridaens R, Van den Bogaert W, Braun S, Janni W, Martin P, Romain S, Hakes T, Hudis CA, Norton L, Wittes R, Giokas G, Kondylis D, Lissaios B, de la Huerta R, Sainz MG, Altemus R, Camphausen K, Cowan K, Danforth D, Lichter A, Lippman M, O'Shaughnessy J, PierceF LJ, Steinberg S, Venzon D, Zujewski JA, D'Amico C, Lioce M, Paradiso A, Chapman JW, Goss PE, Levine MN, Myles JD, Pater JL, Pritchard KI, Shepherd LE, Tu D, Whelan D, Zee B, Nomura Y, Anderson S, Bass G, Brown A, Bryant J, Costantino J, Fisher B, Geyer C, Paik S, Redmond C, Wickerham L, Wolmark N, Baum M, Jackson IM, Palmer MK, Perez E, Ingle JN, Suman VJ, Bengtsson NO, Emdin S, Granstrand B, Jonsson H, Del Mastro L, Venturini M, Lythgoe JP, Swindell R, Kissin M, Erikstein B, Hannisdal E, Jacobsen AB, Varhaug JE, Erikstein B, Gundersen S, Hauer-Jensen M, Høst H, Jacobsen AB, Nissen-Meyer R, Blamey RW, Mitchell AK, Morgan DA, Robertson JF, Di Palma M, Mathé G, Misset JL, Clark RM, LevineF M, Pritchard KI, Whelan T, Morimoto K, Sawa K, Takatsuka Y, Crossley E, Harris A, Talbot D, Taylor M, Martin AL, Roché H, Cocconi G, di Blasio B, Ivanov V, Semiglazov V, Brockschmidt J, Cooper MR, Ueo H, Falkson CI, A'Hern R, Ashley S, Makris A, Powles TJ, Smith IE, Yarnold JR, Gazet JC, Browne L, Graham P, Corcoran N, Deshpande N, di Martino L, Douglas P, Hacking A, Høst H, Lindtner A, Notter G, Bryant AJ, Ewing GH, Firth LA, Krushen-Kosloski JL, Nissen-Meyer R, Foster L, George WD, Stewart HJ, Stroner P, Anderson H, Malmström P, Möller TR, Ringberg A, Rydén L, Tengrup I, Tennvall-Nittby L, Arnesson LG, Carstensen J, Dufmats M, Nordenskjöld B, Söderberg M, Carpenter JT, AlbainF K, Barlow W, CrowleyF J, Hayes D, Gralow J, Green S, Hortobagyi G, Livingston R, Martino S, Osborne CK, Ravdin PM, Murray N, Royle GT, Simmonds PD, Askergren J, Bäckdahl M, Bergh J, Fernstad R, Fornander T, Frisell J, Glas U, Hatschek T, Ideström K, Johansson U, Perbeck L, Rotstein S, Rutqvist LE, Sandelin K, Singnomklao T, Skoog L, Somell A, Wallgren A, Wilking N, Castiglione M, Goldhirsch A, Maibach R, Senn HJ, Thürlimann B, Holli K, Rouhento K, Brenner H, Hercbergs A, Martin AL, Roché H, Yoshimoto M, DeBoer G, Paterson AH, Pritchard KI, Fyles A, Meakin JW, Panzarella T, Pritchard KI, Shan Y, Shao YF, Wang X, Zhao DB, Bahi J, Reid M, Spittle M, Bishop H, Bundred NJ, Cuzick J, Ellis IO, Fentiman IS, Forbes JF, Forsyth S, George WD, Pai VR, Pinder SE, Sestak I, Deutsch GP, KwongF DL, Pai VR, Senanayake F, Bianco AR, Carlomagno C, De Laurentiis M, De Placido S, Broglio K, Buzdar AU, Love RR, Bergh J, Garmo H, Holmberg L, Liljegren G, NilssonF J, Jones SE, Loesch DM, Janauer M, Seifert M, Sevelda P, Zielinski CC, Gluz O, Nitz U, Dunn JA, Hills RK, Lee M, Morrison JM, Poole C, Rea D, Spooner D, Litton A, Wallgren A, Karlsson P, Chlebowski RT, Caffier H.

Abstract

Individual patient data were available for all four of the randomized trials that began before 1995, and that compared adjuvant radiotherapy vs no radiotherapy following breast-conserving surgery for ductal carcinoma in situ (DCIS). A total of 3729 women were eligible for analysis. Radiotherapy reduced the absolute 10-year risk of any ipsilateral breast event (ie, either recurrent DCIS or invasive cancer) by 15.2% (SE 1.6%, 12.9% vs 28.1% 2 P <.00001), and it was effective regardless of the age at diagnosis, extent of breast-conserving surgery, use of tamoxifen, method of DCIS detection, margin status, focality, grade, comedonecrosis, architecture, or tumor size. The proportional reduction in ipsilateral breast events was greater in older than in younger women (2P < .0004 for difference between proportional reductions; 10-year absolute risks: 18.5% vs 29.1% at ages <50 years, 10.8% vs 27.8% at ages ≥ 50 years) but did not differ significantly according to any other available factor. Even for women with negative margins and small low-grade tumors, the absolute reduction in the 10-year risk of ipsilateral breast events was 18.0% (SE 5.5, 12.1% vs 30.1%, 2P = .002). After 10 years of follow-up, there was, however, no significant effect on breast cancer mortality, mortality from causes other than breast cancer, or all-cause mortality.

PMID:
20956824
[PubMed - indexed for MEDLINE]
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