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Ann N Y Acad Sci. 2010 Oct;1207:41-5. doi: 10.1111/j.1749-6632.2010.05731.x.

The role of the blood transcriptome in innate inflammation and stroke.

Author information

  • 1Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA. freedmaj@bu.edu

Abstract

Cerebrovascular disease is a major cause of death and disability, with a poorer outcome in patients having select risk factors including diabetes and hypertension. Risk factors and the state of cerebral ischemia-reperfusion associated with cerebrovascular occlusion are known to cause inflammatory changes. These events and the inflammatory state are reflected by transcript changes in various components of the blood and can be specifically measured. By defining these changes, new insight into cerebrovascular disease and its therapeutics is being achieved.

© 2010 New York Academy of Sciences.

PMID:
20955424
[PubMed - indexed for MEDLINE]
PMCID:
PMC2958681
Free PMC Article

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