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Nat Neurosci. 2010 Nov;13(11):1345-7. doi: 10.1038/nn.2658. Epub 2010 Oct 17.

Fezf2 directs the differentiation of corticofugal neurons from striatal progenitors in vivo.

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  • 1Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.


In the developing cerebral cortex, cell-extrinsic and cell-intrinsic signals govern the establishment of neuron subtype-specific identity. Here we show that, within the niche of the striatum, the expression of a single transcription factor, Fezf2, is sufficient to generate corticofugal neurons from progenitors fated to become medium spiny neurons. This demonstrates that a specific population of cortical projection neurons can be directed to differentiate outside of the cortex by cell-autonomous signaling.

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