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Ann Oncol. 2011 Apr;22(4):910-5. doi: 10.1093/annonc/mdq549. Epub 2010 Oct 15.

End-of-treatment but not interim PET scan predicts outcome in nonbulky limited-stage Hodgkin's lymphoma.

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  • 1Center for Lymphoma, Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.

Abstract

BACKGROUND:

Early interim positron emission tomography (PET) scans appear powerfully predictive of outcome in Hodgkin's lymphoma (HL), particularly in advanced-stage disease where it has been predominantly studied. The prognostic value of interim PET in limited-stage patients with nonbulky disease has not been well established.

PATIENTS AND METHODS:

Ninety-six patients with nonbulky limited-stage HL were identified who had interim and end-of-treatment PET scans. Response rate, overall survival (OS), and progression-free survival (PFS) were calculated.

RESULTS:

Four-year PFS and OS for the entire cohort were 88% and 97%, respectively. Interim PET did not predict outcome, with PFS in positive and negative patients 87% versus 91% (P=0.57), respectively. End-of-treatment PET result was predictive of outcome, with PFS of 94% in end PET-negative patients versus 54% in end PET-positive patients (P<0.0001). Four-year OS was 100% in end PET-negative patients and 84% in end PET-positive patients (P<0.0001).

CONCLUSIONS:

Interim PET scans were not predictive of outcome, compared with scans carried out at completion of therapy. End-of-treatment PET was highly predictive of PFS and OS, regardless of interim PET result. In this low-risk patient population, even patients with interim positive PET scans show a favorable prognosis.

© The Author 2010. Published by Oxford University Press on behalf of the European Society for Medical Oncology.

PMID:
20952598
[PubMed - indexed for MEDLINE]
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