Format

Send to:

Choose Destination
See comment in PubMed Commons below
IEEE Trans Inf Technol Biomed. 2011 Mar;15(2):195-205. doi: 10.1109/TITB.2010.2087343. Epub 2010 Oct 14.

A hybrid clustering method for ROI delineation in small-animal dynamic PET images: application to the automatic estimation of FDG input functions.

Author information

  • 1Department of Electronic and Information Engineering, The Hong Kong Polytechnic University, Hong Kong. zhengxj@eie.polyu.edu.hk

Abstract

Tracer kinetic modeling with dynamic positron emission tomography (PET) requires a plasma time-activity curve (PTAC) as an input function. Several image-derived input function (IDIF) methods that rely on drawing the region of interest (ROI) in large vascular structures have been proposed to overcome the problems caused by the invasive approach for obtaining the PTAC, especially for small-animal studies. However, the manual placement of ROIs for estimating IDIF is subjective and labor-intensive, making it an undesirable and unreliable process. In this paper, we propose a novel hybrid clustering method (HCM) that objectively delineates ROIs in dynamic PET images for the estimation of IDIFs, and demonstrate its application to the mouse PET studies acquired with [ (18)F]Fluoro-2-deoxy-2-D-glucose (FDG). We begin our HCM using k-means clustering for background removal. We then model the time-activity curves using polynomial regression mixture models in curve clustering for heart structure detection. The hierarchical clustering is finally applied for ROI refinements. The HCM achieved accurate ROI delineation in both computer simulations and experimental mouse studies. In the mouse studies, the predicted IDIF had a high correlation with the gold standard, the PTAC derived from the invasive blood samples. The results indicate that the proposed HCM has a great potential in ROI delineation for automatic estimation of IDIF in dynamic FDG-PET studies.

PMID:
20952342
[PubMed - indexed for MEDLINE]
PMCID:
PMC3071356
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for IEEE Engineering in Medicine and Biology Society Icon for PubMed Central
    Loading ...
    Write to the Help Desk