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Cancer Cell. 2010 Oct 19;18(4):297-9. doi: 10.1016/j.ccr.2010.10.003.

T-lineage lymphoblastic lymphoma and leukemia-a MASSive problem.

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  • Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. charles.mullighan@stjude.org


T cell precursor malignancies may present as T-lymphoblastic lymphoma (T-LBL) with marked enlargement of lymph nodes or acute T-lymphoblastic leukemia (T-ALL) with little lymph node enlargement. In this issue of Cancer Cell, Feng et al. show that dysregulation of BCL2, AKT signaling, and cell adhesion pathways are hallmarks of T-LBL.

Copyright © 2010 Elsevier Inc. All rights reserved.

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