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Semin Cancer Biol. 2010 Oct;20(5):281-93. doi: 10.1016/j.semcancer.2010.10.009. Epub 2010 Oct 15.

DNA replication fidelity and cancer.

Author information

  • 1Department of Pathology, University of Washington, Seattle, WA 98195, USA. bradp@u.washington.edu

Abstract

Cancer is fueled by mutations and driven by adaptive selection. Normal cells avoid deleterious mutations by replicating their genomes with extraordinary accuracy. Here we review the pathways governing DNA replication fidelity and discuss evidence implicating replication errors (point mutation instability or PIN) in carcinogenesis.

Copyright © 2010 Elsevier Ltd. All rights reserved.

PMID:
20951805
[PubMed - indexed for MEDLINE]
PMCID:
PMC2993855
Free PMC Article
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