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Microbes Infect. 2011 Jan;13(1):14-24. doi: 10.1016/j.micinf.2010.09.011. Epub 2010 Oct 15.

SIV infection in natural hosts: resolution of immune activation during the acute-to-chronic transition phase.

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  • 1Seattle Biomedical Research Institute, Seattle, WA, USA.


SIV-infected natural hosts do not progress to clinical AIDS yet display high viral replication and an acute immunologic response similar to pathogenic SIV/HIV infections. During chronic SIV infection, natural hosts suppress their immune activation, whereas pathogenic hosts display a highly activated immune state. Here, we review natural host SIV infections with an emphasis on specific immune cells and their contribution to the transition from the acute-to-chronic phases of infection.

Copyright © 2010 Institut Pasteur. Published by Elsevier SAS. All rights reserved.

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