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Int J Radiat Oncol Biol Phys. 2011 Feb 1;79(2):571-8. doi: 10.1016/j.ijrobp.2010.08.019. Epub 2010 Oct 13.

Tocopherol succinate: modulation of antioxidant enzymes and oncogene expression, and hematopoietic recovery.

Author information

  • 1Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA. singh@afrri.usuhs.mil

Abstract

PURPOSE:

A class of naturally occurring isoforms of tocopherol (tocols) was shown to have varying degrees of protection when administered before radiation exposure. We recently demonstrated that α-tocopherol succinate (TS) is a potential radiation prophylactic agent. Our objective in this study was to further investigate the mechanism of action of TS in mice exposed to (60)Co γ-radiation.

METHODS AND MATERIALS:

We evaluated the effects of TS on expression of antioxidant enzymes and oncogenes by quantitative RT-PCR in bone marrow cells of (60)Co γ-irradiated mice. Further, we tested the ability of TS to rescue and repopulate hematopoietic stem cells by analyzing bone marrow cellularity and spleen colony forming unit in spleen of TS-injected and irradiated mice.

RESULTS:

Our results demonstrate that TS modulated the expression of antioxidant enzymes and inhibited expression of oncogenes in irradiated mice at different time points. TS also increased colony forming unit-spleen numbers and bone marrow cellularity in irradiated mice.

CONCLUSIONS:

Results provide additional support for the observed radioprotective efficacy of TS and insight into mechanisms.

Published by Elsevier Inc.

PMID:
20950962
[PubMed - indexed for MEDLINE]
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