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    Bioconjug Chem. 2010 Nov 17;21(11):1978-86. Epub 2010 Oct 15.

    Self-protecting bactericidal titanium alloy surface formed by covalent bonding of daptomycin bisphosphonates.

    Chen CP, Wickstrom E.

    Source

    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, United States.

    Abstract

    Infections are a devastating complication of titanium alloy orthopedic implants. Current therapy includes antibiotic-impregnated bone cement and antibiotic-containing coatings. We hypothesized that daptomycin, a Gram-positive peptide antibiotic, could prevent bacterial colonization on titanium alloy surfaces if covalently bonded via a flexible, hydrophilic spacer. We designed and synthesized a series of daptomycin conjugates for bonding to the surface of 1.0 cm² Ti6Al4V foils through bisphosphonate groups, reaching a maximum yield of 180 pmol/cm². Daptomycin-bonded foils killed 53 ± 5% of a high challenge dose of 3 × 10⁵ cfu Staphylococcus aureus ATCC 29213.

    PMID:
    20949909
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2987735
    Free PMC Article

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