Format

Send to

Choose Destination
See comment in PubMed Commons below
Cancer Res Treat. 2010 Sep;42(3):151-6. doi: 10.4143/crt.2010.42.3.151. Epub 2010 Sep 30.

Up-regulation of RhoGDI2 in human breast cancer and its prognostic implications.

Author information

  • 1Department of Surgery, Seoul National University Hospital, Seoul, Korea.

Abstract

PURPOSE:

Recent research has identified many genes and proteins that play specific roles in the process of systemic metastasis in various types of cancer. Rho GDP dissociation inhibitor 2 (RhoGDI2) has been shown to inhibit metastasis in human bladder cancer, but its role in breast cancer is controversial.

MATERIALS AND METHODS:

We examined the regulation and clinical significance of RhoGDI2 in Korean breast cancer patients by using proteomic approaches.

RESULTS:

By using a proteomic approach, we observed an increased expression of RhoGDI2 in human breast cancer tissues when compared to that of the normal breast tissues, and we validated its up-regulation in an independent cohort of 8 breast cancer patients. The clinical implication of a RhoGDI2 expression was investigated in 57 breast cancer patients by performing immunohistochemistry. RhoGDI2 did not show a significant association with the tumor size, lymph node metastasis, the histologic grade or the hormone receptor status. However, the patients with RhoGDI2-expressing tumors had significantly shorter disease-free survival (p=0.043; hazard ratio, 3.87) and distant metastasis-free survival (p=0.039; hazard ratio, 5.15).

CONCLUSION:

Our results demonstrated a potential role of RhoGDI2 as a poor prognostic marker as well as a potential therapeutic target. The pro-metastatic nature of RhoGDI2 shown in our study may indicate its organ-specific role in cancer metastasis.

KEYWORDS:

Breast neoplasms; Neoplasm metastasis; Prognosis; Proteomics; RhoGDI2 protein

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Publishing M2Community Icon for PubMed Central
    Loading ...
    Write to the Help Desk