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F1000 Biol Rep. 2009 Mar 24;1:23. doi: 10.3410/B1-23.

The ABCB1 transporter gene and antidepressant response.

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  • 1Illumina Inc, 9865 Towne Centre Drive, San Diego, CA 92121-1975, USA.


P-glycoprotein, encoded by the ABCB1 gene, may modulate the brain concentration of several antidepressants. Functional genetic variation is thought to exist in this gene, and here we review several studies that have attempted to associate this variation with clinical response to antidepressant treatment.

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