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F1000 Biol Rep. 2009 Jul 27;1:58. doi: 10.3410/B1-58.

Cell biology of mechanotransduction in inner-ear hair cells.

Author information

  • Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School 220 Longwood Avenue, Boston, MA 02115 USA. dcorey@hms.harvard.edu

Abstract

The cloning of deafness genes, especially those for Usher syndrome, has helped to identify a variety of structural proteins involved in the development and function of hair-cell stereocilia. These include novel cadherins, a handful of myosin motors, and scaffolding proteins. Yet a new understanding of these proteins has upended the orthodox view of mechanosensation by hair cells.

PMID:
20948626
[PubMed]
PMCID:
PMC2948250
Free PMC Article

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