Thymic egress: S1P of 1000

F1000 Biol Rep. 2009 Aug 17:1:60. doi: 10.3410/B1-60.

Abstract

Recent studies have begun to illuminate the mechanism of T-cell export from the thymus, with the identification of a required lysophospholipid receptor, two upstream transcription factors, and several downstream regulators of cytoskeleton dynamics. This work has generated immediate translational impact, aiding the design of immunosuppressant drugs and the identification of a novel form of human immunodeficiency.