Bull World Health Organ. 1990;68 Suppl:9-12.

Immunity to falciparum and vivax malaria induced by irradiated sporozoites: a review of the University of Maryland studies, 1971-75.

Source

Department of Medicine, University of Maryland School of Medicine, Baltimore.

Abstract

The immunogenicity in adult male volunteers of sporozoites of Plasmodium falciparum and P. vivax was evaluated at the University of Maryland from 1971 to 1975. Inoculation of large numbers of sporozoites by mosquitos that had been X-irradiated proved safe and well tolerated, and the sporozoites were rendered noninfective. Three volunteers were protectively immunized by this method, one against P. falciparum, one against P. vivax, and one against both species. Protection was species- and stage-specific, but effective against all strains tested within a species, and was reflected by a rise in titre of antibody to the circumsporozoite protein.

PMID:: 2094597; [PubMed - indexed for MEDLINE]
PMCID:: PMC2393030

Free PMC Article

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Antigens, Protozoan

LinkOut - more resources

Full Text Sources

Medical

ClinicalTrials.gov

Supplemental Content

Save items

Related citations in PubMed

Immunization of man against falciparum and vivax malaria by use of attenuated sporozoites. [Am J Trop Med Hyg. 1975]
Immunization of man against falciparum and vivax malaria by use of attenuated sporozoites.
Clyde DF. Am J Trop Med Hyg. 1975 May; 24(3):397-401.
Human immunization with attenuated sporozoites. [Bull World Health Organ. 1990]
Human immunization with attenuated sporozoites.
Rieckmann KH. Bull World Health Organ. 1990; 68 Suppl:13-6.
Immunogenicity of Plasmodium falciparum and Plasmodium vivax circumsporozoite protein repeat multiple antigen constructs (MAC). [Vaccine. 1998]
Immunogenicity of Plasmodium falciparum and Plasmodium vivax circumsporozoite protein repeat multiple antigen constructs (MAC).
Udhayakumar V, Saekhou A, Fang S, Jue D, Wohlhueter RM, Lal AA. Vaccine. 1998 May-Jun; 16(9-10):982-8.
Review Pre-erythrocytic malaria vaccine: mechanisms of protective immunity and human vaccine trials. [Parassitologia. 1999]
Review Pre-erythrocytic malaria vaccine: mechanisms of protective immunity and human vaccine trials.
Nardin E, Zavala F, Nussenzweig V, Nussenzweig RS. Parassitologia. 1999 Sep; 41(1-3):397-402.
Review Experimental basis for the development of a synthetic vaccine against Plasmodium falciparum malaria sporozoites. [Ciba Found Symp. 1986]
Review Experimental basis for the development of a synthetic vaccine against Plasmodium falciparum malaria sporozoites.
Nussenzweig V, Nussenzweig R. Ciba Found Symp. 1986; 119:150-63.

See reviews... See all...

Cited by 17 PubMed Central articles

Immune responses and protection of Aotus monkeys immunized with irradiated Plasmodium vivax sporozoites. [Am J Trop Med Hyg. 2011]
Immune responses and protection of Aotus monkeys immunized with irradiated Plasmodium vivax sporozoites.
Jordán-Villegas A, Perdomo AB, Epstein JE, López J, Castellanos A, Manzano MR, Hernández MA, Soto L, Méndez F, Richie TL, et al. Am J Trop Med Hyg. 2011 Feb; 84(2 Suppl):43-50.
Antibody-mediated and cellular immune responses induced in naive volunteers by vaccination with long synthetic peptides derived from the Plasmodium vivax circumsporozoite protein. [Am J Trop Med Hyg. 2011]
Antibody-mediated and cellular immune responses induced in naive volunteers by vaccination with long synthetic peptides derived from the Plasmodium vivax circumsporozoite protein.
Arévalo-Herrera M, Soto L, Perlaza BL, Céspedes N, Vera O, Lenis AM, Bonelo A, Corradin G, Herrera S. Am J Trop Med Hyg. 2011 Feb; 84(2 Suppl):35-42.
Preclinical vaccine study of Plasmodium vivax circumsporozoite protein derived-synthetic polypeptides formulated in montanide ISA 720 and montanide ISA 51 adjuvants. [Am J Trop Med Hyg. 2011]
Preclinical vaccine study of Plasmodium vivax circumsporozoite protein derived-synthetic polypeptides formulated in montanide ISA 720 and montanide ISA 51 adjuvants.
Arévalo-Herrera M, Vera O, Castellanos A, Céspedes N, Soto L, Corradin G, Herrera S. Am J Trop Med Hyg. 2011 Feb; 84(2 Suppl):21-7.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Immunity to falciparum and vivax malaria induced by irradiated sporozoites: a re...
Immunity to falciparum and vivax malaria induced by irradiated sporozoites: a review of the University of Maryland studies, 1971-75.
Bull World Health Organ. 1990 ;68 Suppl:9-12.

PubMed
Adiponectin inhibits spontaneous and catecholamine-induced lipolysis in human ad...
Adiponectin inhibits spontaneous and catecholamine-induced lipolysis in human adipocytes of non-obese subjects through AMPK-dependent mechanisms.
Physiol Res. 2011 ;60(1):139-48. Epub 2010 Oct 15 .

PubMed
The nonribosomal peptide synthetase enzyme DdaD tethers N(β)-fumaramoyl-l-2,3-di...
The nonribosomal peptide synthetase enzyme DdaD tethers N(β)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis.
J Am Chem Soc. 2010 Nov 10 ;132(44):15773-81.

PubMed
Antibody responses to Plasmodium falciparum and P. vivax sporozoites in areas wi...
Antibody responses to Plasmodium falciparum and P. vivax sporozoites in areas with stable and unstable malaria.
Bull World Health Organ. 1990 ;68 Suppl:191-6.

PubMed
Aptamers as Affinity Reagents in an Integrated Electrophoretic Lab-on-a-Chip Pla...
Aptamers as Affinity Reagents in an Integrated Electrophoretic Lab-on-a-Chip Platform.
Anal Chem. 2010 Oct 14. [Epub ahead of print]

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: