Bull World Health Organ. 1990;68 Suppl:13-6.

Human immunization with attenuated sporozoites.

Source

Army Malaria Research Unit, University of Sydney.

Abstract

Studies conducted between 1971 and 1975 showed that attenuated sporozoites can induce protection against human malaria. Three volunteers were protected against challenge with either a homologous or heterologous strain of Plasmodium falciparum after being exposed to a total of 440-987 X-irradiated mosquitos on 6-8 occasions over a period of 10-38 weeks. Protection lasted for at least 8 weeks, but not 16 weeks, after the last immunization with irradiated sporozoites. Another 7 volunteers were not protected against challenge with a homologous strain after exposure to a total of fewer than 200 irradiated mosquitos, infected with either P. falciparum or P. vivax, on 2-4 occasions over a period of 4-17 weeks. These studies provide an encouraging basis for pursuing the development of a sporozoite vaccine against human malaria.

PMID:: 2094578; [PubMed - indexed for MEDLINE]
PMCID:: PMC2393053

Free PMC Article

MeSH Terms, Substances

MeSH Terms

Substances

Vaccines, Attenuated

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Use of attenuated sporozoites in the immunization of human volunteers against falciparum malaria. [Bull World Health Organ. 1979]
Use of attenuated sporozoites in the immunization of human volunteers against falciparum malaria.
Rieckmann KH, Beaudoin RL, Cassells JS, Sell KW. Bull World Health Organ. 1979; 57 Suppl 1:261-5.
Review Immunity to falciparum and vivax malaria induced by irradiated sporozoites: a review of the University of Maryland studies, 1971-75. [Bull World Health Organ. 1990]
Review Immunity to falciparum and vivax malaria induced by irradiated sporozoites: a review of the University of Maryland studies, 1971-75.
Clyde DF. Bull World Health Organ. 1990; 68 Suppl:9-12.
Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites. [J Infect Dis. 2002]
Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites.
Hoffman SL, Goh LM, Luke TC, Schneider I, Le TP, Doolan DL, Sacci J, de la Vega P, Dowler M, Paul C, et al. J Infect Dis. 2002 Apr 15; 185(8):1155-64. Epub 2002 Apr 1.
Immunization of man against falciparum and vivax malaria by use of attenuated sporozoites. [Am J Trop Med Hyg. 1975]
Immunization of man against falciparum and vivax malaria by use of attenuated sporozoites.
Clyde DF. Am J Trop Med Hyg. 1975 May; 24(3):397-401.
Review Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccine. [J Exp Biol. 2003]
Review Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccine.
Luke TC, Hoffman SL. J Exp Biol. 2003 Nov; 206(Pt 21):3803-8.

See reviews... See all...

Cited by 10 PubMed Central articles

Immune responses and protection of Aotus monkeys immunized with irradiated Plasmodium vivax sporozoites. [Am J Trop Med Hyg. 2011]
Immune responses and protection of Aotus monkeys immunized with irradiated Plasmodium vivax sporozoites.
Jordán-Villegas A, Perdomo AB, Epstein JE, López J, Castellanos A, Manzano MR, Hernández MA, Soto L, Méndez F, Richie TL, et al. Am J Trop Med Hyg. 2011 Feb; 84(2 Suppl):43-50.
Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites. [PLoS Pathog. 2010]
Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites.
Schmidt NW, Butler NS, Badovinac VP, Harty JT. PLoS Pathog. 2010 Jul 15; 6(7):e1000998. Epub 2010 Jul 15.
Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model. [PLoS One. 2010]
Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model.
Guilbride DL, Gawlinski P, Guilbride PD. PLoS One. 2010 May 19; 5(5):e10685. Epub 2010 May 19.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Human immunization with attenuated sporozoites.
Human immunization with attenuated sporozoites.
Bull World Health Organ. 1990 ;68 Suppl:13-6.

PubMed
Quantifying fire severity, carbon, and nitrogen emissions in Alaska's boreal for...
Quantifying fire severity, carbon, and nitrogen emissions in Alaska's boreal forest.
Ecol Appl. 2010 Sep ;20(6):1633-47.

PubMed
[Socioeconomic aspects of human immunodeficiency virus (HIV) infection in develo...
[Socioeconomic aspects of human immunodeficiency virus (HIV) infection in developing countries].
Bull Acad Natl Med. 1990 Nov ;174(8):1209-19; discussion 1219-21.

PubMed
Re: MicroRNA regulation of oncolytic herpes simplex virus-1 for selective killin...
Re: MicroRNA regulation of oncolytic herpes simplex virus-1 for selective killing of prostate cancer cells.
Eur Urol. 2010 May ;57(5):919.

PubMed
AMACR polymorphisms, dietary intake of red meat and dairy and prostate cancer ri...
AMACR polymorphisms, dietary intake of red meat and dairy and prostate cancer risk.
Prostate. 2011 Apr ;71(5):498-506. doi: 10.1002/pros.21267. Epub 2010 Oct 13 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: