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Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10):1148-52. doi: 10.1107/S1744309110001685. Epub 2010 Mar 5.

DUFs: families in search of function.

Author information

  • 1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, England. agb@sanger.ac.uk

Abstract

Domains of unknown function (DUFs) are a large set of uncharacterized protein families that are found in the Pfam database. Here, the scale and growth of functionally uncharacterized families in biological databases are surveyed and the prospects for discovering their function are examined. In particular, the important role that structural genomics can play in identifying potential function is evaluated.

PMID:
20944204
[PubMed - indexed for MEDLINE]
PMCID:
PMC2954198
Free PMC Article

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