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Bioorg Med Chem Lett. 2010 Nov 15;20(22):6542-6. doi: 10.1016/j.bmcl.2010.09.036. Epub 2010 Sep 21.

Synthesis and biological evaluation of [D-lysine]8cyclosporin A analogs as potential anti-HCV agents.

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  • 1SCYNEXIS, Inc., PO Box 12878, Research Triangle Park, NC 27709-2878, USA.


An efficient synthesis of [D-lysine](8)cyclosporin A has been developed. Several analogs of [D-lysine](8)cyclosporin A have been synthesized and show promising anti-HCV activity, particularly compounds 39 and 43, which each exhibit an anti-HCV EC(50)<200 nM, and are each ≥50-fold less immunosuppressive than cyclosporin A.

Copyright © 2010 Elsevier Ltd. All rights reserved.

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