Intensive Care Med. 1990;16(2):75-80.

Management of autonomic dysfunction in severe tetanus: the use of magnesium sulphate and clonidine.

Sutton DN, Tremlett MR, Woodcock TE, Nielsen MS.

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Shackleton Department of Anaesthetics, Southampton General Hospital, UK.

Abstract

The treatment of severe tetanus with autonomic dysfunction is discussed, with emphasis on the use of magnesium sulphate. An exemplary case is reported, describing the inadequate response to magnesium, but the previously unreported and successful use of clonidine to control sympathetic overactivity. The properties of clonidine are reviewed. Clonidine is felt to be a logical and appropriate drug for the treatment of autonomic dysfunction in severe tetanus.

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Intensive Care Med. 1990;16(8):520.

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