Purinergic activation of dorsal root ganglion neurones in vivo

Neurosci Lett. 2011 Jan 3;487(1):107-9. doi: 10.1016/j.neulet.2010.10.005. Epub 2010 Oct 16.

Abstract

Functional relevance of non-synaptic purinergic receptors on dorsal root ganglion cells was tested in vivo by the influence of ATP using 2P-LSM and Ca imaging. Within a few seconds after local application of ATP, neurones in dorsal root ganglion were activated indicated by an increase of their calcium signal. The signal reached its maximum within a few seconds and declined to control values after about 30 s. Purinergic action seems to include non-synaptic cell-to-cell communication within dorsal root ganglia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / pharmacology
  • Animals
  • Calcium / metabolism
  • Dose-Response Relationship, Drug
  • Ganglia, Spinal / cytology*
  • Green Fluorescent Proteins / genetics
  • Mice
  • Mice, Transgenic
  • Microscopy, Confocal / methods
  • Purines / metabolism*
  • Sensory Receptor Cells / drug effects
  • Sensory Receptor Cells / metabolism*
  • Time Factors

Substances

  • Purines
  • enhanced green fluorescent protein
  • Green Fluorescent Proteins
  • Adenosine Triphosphate
  • Calcium
  • purine