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J Infect Dis. 2010 Nov 15;202(10):1482-5. doi: 10.1086/657167. Epub 2010 Oct 11.

Failure to detect xenotropic murine leukemia virus-related virus in blood of individuals at high risk of blood-borne viral infections.

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  • 1Nuffield Department of Clinical Medicine, Peter Medawar Building for Pathogen Research, Oxford University, and Oxford NIHR Biomedical Research Centre, Oxford, United Kingdom.

Abstract

A xenotropic murine leukemia virus-related virus (XMRV) has recently been reported in association with prostate cancer and chronic fatigue syndrome, with a prevalence of up to 3.7% in the healthy population. We looked for XMRV in 230 patients with human immunodeficiency virus type 1 or hepatitis C infection. XMRV was undetectable in plasma or peripheral blood mononuclear cells by polymerase chain reaction targeting XMRV gag or env. T cell responses to XMRV Gag were undetectable in peripheral blood mononuclear cells by ex vivo gamma interferon enzyme-linked immunospot assay. In our cohorts, XMRV was not enriched in patients with blood-borne or sexually transmitted infections from the United Kingdom and Western Europe.

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PMID:
20936982
[PubMed - indexed for MEDLINE]
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