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Nat Med. 2010 Nov;16(11):1295-8. doi: 10.1038/nm.2238. Epub 2010 Oct 10.

Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1.

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  • 1Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA.

Abstract

Hepatitis C virus (HCV) infection is closely tied to the lipid metabolism of liver cells. Here we identify the triglyceride-synthesizing enzyme diacylglycerol acyltransferase-1 (DGAT1) as a key host factor for HCV infection. DGAT1 interacts with the viral nucleocapsid core and is required for the trafficking of core to lipid droplets. Inhibition of DGAT1 activity or RNAi-mediated knockdown of DGAT1 severely impairs infectious virion production, implicating DGAT1 as a new target for antiviral therapy.

PMID:
20935628
[PubMed - indexed for MEDLINE]
PMCID:
PMC3431199
Free PMC Article
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