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Appl Environ Microbiol. 2010 Dec;76(24):8255-8. doi: 10.1128/AEM.00499-10. Epub 2010 Oct 8.

Identification of synthetic inducers and inhibitors of the quorum-sensing regulator LasR in Pseudomonas aeruginosa by high-throughput screening.

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  • 1Department of Plant Pathology, University of Wisconsin—Madison, Madison, Wisconsin 53706, USA.


We report the screening of 16,000 synthetic compounds for induction and inhibition of quorum sensing in a Pseudomonas putida N-acylated l-homoserine lactone (AHL) sensor strain engineered with the LasR transcriptional activator. LasR controls virulence gene expression in the opportunistic pathogen Pseudomonas aeruginosa and is of significant interest as a therapeutic target. Nine compounds that inhibit and 14 compounds that induce LasR activity were identified in our high-throughput screen.

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