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Life Sci. 2010 Dec 18;87(23-26):659-66. doi: 10.1016/j.lfs.2010.10.003. Epub 2010 Oct 8.

Functions of B56-containing PP2As in major developmental and cancer signaling pathways.

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  • 1The Research Institute at Nationwide Children's Hospital, Department of Pediatrics, the Ohio State University, 700 Children's Dr., Columbus, OH, 43205, United States. Jing.Yang@nationwidechildrens.org

Abstract

Members of the B'/B56/PR61 family regulatory subunits of PP2A determine the subcellular localization, substrate specificity, and catalytic activity of PP2A in a wide range of biological processes. Here, we summarize the structure and intracellular localization of B56-containing PP2As and review functions of B56-containing PP2As in several major developmental/cancer signaling pathways.

Copyright © 2010 Elsevier Inc. All rights reserved.

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