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Reprod Toxicol. 2011 Feb;31(2):158-63. doi: 10.1016/j.reprotox.2010.09.013. Epub 2010 Oct 8.

Associations between blood metals and fecundity among women residing in New York State.

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  • 1Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, One University Place, Rensselaer, NY 12144, USA. mbloom@uamail.albany.edu

Abstract

Trace exposures to metals may affect female reproductive health. To assess the relation between trace concentrations of blood metals and female fecundity, 99 non-pregnant women discontinuing contraception for the purpose of becoming pregnant were prospectively followed. Participants completed a baseline interview and daily diaries until pregnant, or up to 12 menstrual cycles at risk for pregnancy; home pregnancy test kits were used. For 80 women, whole blood specimens were analyzed for arsenic, cadmium, lead, magnesium, nickel, selenium and zinc using inductively coupled plasma mass spectrometry (ICP-MS). Time to pregnancy was estimated using Cox proportional hazards models for discrete time. Metal concentrations were generally within population reference intervals. Adjusted models suggest a 51.5% increase in the probability for pregnancy per 3.60 μg/L increase in Mg (P=0.062), and a 27.7% decrease per 0.54 μg/L increase in Zn (P=0.114). Findings indicate that Mg and Zn may impact female fecundity, but in varying directions.

Copyright © 2010 Elsevier Inc. All rights reserved.

PMID:
20933593
[PubMed - indexed for MEDLINE]
PMCID:
PMC3039711
Free PMC Article
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