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Semin Cell Dev Biol. 2011 Apr;22(2):153-9. doi: 10.1016/j.semcdb.2010.09.009. Epub 2010 Oct 12.

Mass spectrometry-based phosphoproteomics reveals multisite phosphorylation on mammalian brain voltage-gated sodium and potassium channels.

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  • 1Department of Neurobiology, Physiology and Behavior, University of California, Davis, CA 95616-8519, United States.


Voltage-gated sodium and potassium channels underlie electrical activity of neurons, and are dynamically regulated by diverse cell signaling pathways that ultimately exert their effects by altering the phosphorylation state of channel subunits. Recent mass spectrometric-based studies have led to a new appreciation of the extent and nature of phosphorylation of these ion channels in mammalian brain. This has allowed for new insights into how neurons dynamically regulate the localization, activity and expression through multisite ion channel phosphorylation.

Copyright © 2010 Elsevier Ltd. All rights reserved.

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