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Immunol Res. 2011 May;50(1):49-68. doi: 10.1007/s12026-010-8173-y.

On the logic of restrictive recognition of peptide by the T-cell antigen receptor.

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  • 1Conceptual Immunology Group, The Salk Institute For Biological Studies, La Jolla, CA 92037, USA. cohn@salk.edu

Abstract

This essay provides an analysis of the inadequacy of the current view of restrictive recognition of peptide by the T-cell antigen receptor. A competing model is developed, and the experimental evidence for the prevailing model is reinterpreted in the new framework. The goal is to contrast the two models with respect to their consistency, coverage of the data, explanatory power, and predictability.

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