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AIDS Res Hum Retroviruses. 2011 Feb;27(2):179-82. doi: 10.1089/aid.2010.0090. Epub 2010 Oct 7.

Short communication: quantitative proteomic plasma profiling reveals activation of host defense to oxidative stress in chronic SIV and methamphetamine comorbidity.

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  • 1Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, 68198-5800, USA.

Abstract

The double epidemic of substance abuse and HIV infection is a multifaceted problem To investigate mechanistic clues to the effects of substance abuse on infected individuals we preformed quantitative proteomic profiling of plasma in a methamphetamine treated nonhuman primate model for AIDS. A nontargeted quantitative approach identified extracellular superoxide dismutase to be significantly upregulated by SIV and methamphetamine treatment, and targeted studies revealed an increase in expression in the antioxidant glutathione S-transferase, thus pointing to a compensatory response to increased oxidative stress in methamphetamine-treated animals.

PMID:
20929344
[PubMed - indexed for MEDLINE]
PMCID:
PMC3045074
Free PMC Article

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