Bringing natural products into the fold - exploring the therapeutic lead potential of secondary metabolites for the treatment of protein-misfolding-related neurodegenerative diseases

Nat Prod Rep. 2011 Jan;28(1):26-47. doi: 10.1039/c0np00017e. Epub 2010 Oct 7.

Abstract

A review with 187 references, describing natural products that exhibit bioactive properties relevant to the treatment of protein aggregation-related neurodegenerative diseases (e.g., Huntington's, Parkinson's, and prion diseases) and comparing the chemical properties of these secondary metabolite leads to compounds in clinical use for treating central nervous system conditions.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Biological Products* / chemistry
  • Biological Products* / pharmacology
  • Biological Products* / therapeutic use
  • Humans
  • Molecular Structure
  • Neurodegenerative Diseases / drug therapy*
  • Proteostasis Deficiencies*

Substances

  • Biological Products