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J Diabetes Sci Technol. 2010 Sep 1;4(5):1238-47.

Tissue engineering approaches to enhancing clinical islet transplantation through tissue engineering strategies.

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  • 1Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA.

Abstract

Clinical islet transplantation (CIT), the infusion of allogeneic islets within the liver, has the potential to provide precise and sustainable control of blood glucose levels for the treatment of type 1 diabetes. The success and long-term outcomes of CIT, however, are limited by obstacles such as a nonoptimal transplantation site and severe inflammatory and immunological responses to the transplant. Tissue engineering strategies are poised to combat these challenges. In this review, emerging methods for engineering an optimal islet transplantation site, as well as novel approaches for improving islet cell encapsulation, are discussed.

© 2010 Diabetes Technology Society.

PMID:
20920446
PMCID:
PMC2956806
[PubMed - indexed for MEDLINE]
Free PMC Article
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