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Genome Biol. 2010;11(9):R96. doi: 10.1186/gb-2010-11-9-r96. Epub 2010 Sep 29.

Multi-species integrative biclustering.

Author information

  • 1Computer Science Department, Warren Weaver Hall (Room 305), 251 Mercer Street, New York, NY 10012, USA. waltman@cs.nyu.edu

Abstract

We describe an algorithm, multi-species cMonkey, for the simultaneous biclustering of heterogeneous multiple-species data collections and apply the algorithm to a group of bacteria containing Bacillus subtilis, Bacillus anthracis, and Listeria monocytogenes. The algorithm reveals evolutionary insights into the surprisingly high degree of conservation of regulatory modules across these three species and allows data and insights from well-studied organisms to complement the analysis of related but less well studied organisms.

PMID:
20920250
[PubMed - indexed for MEDLINE]
PMCID:
PMC2965388
Free PMC Article

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