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Pediatr Diabetes. 2011 May;12(3 Pt 1):156-64. doi: 10.1111/j.1399-5448.2010.00678.x. Epub 2010 Sep 7.

Low zinc in drinking water is associated with the risk of type 1 diabetes in children.

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  • 1Division of Paediatrics, Department of Molecular and Clinical Medicine, Linkoping University, Linkoping, Sweden.



To explore if drinking water may influence the development of type 1 diabetes in children, either via enterovirus spread via drinking water or quality of drinking water related to acidity or concentration of certain minerals.


One hundred and forty-two families with a child with diabetes and who lived either in seven municipalities with a high annual diabetes incidence during 1977-2001 and in six municipalities with the lowest incidence during those 25 yr were asked to participate. Three hundred and seventy-three families in these communities were used as controls. The families filled a 200-mL plastic bottle with their tap drinking water and returned it by mail. The water samples were analyzed for pH, zinc, iron, nitrate, nitrite, nitrate-nitrogen and nitrite-nitrogen, and occurrence of enterovirus RNA.


Enterovirus RNA was not found in the tap water samples. The concentration of zinc, nitrate, and nitrate-nitrogen was lower in the municipalities with high incidence of type 1 diabetes. The water samples from families with a child with diabetes had lower concentration of zinc than water samples from control families.


Low zinc in drinking water is associated with the risk of developing type 1 diabetes during childhood. Enterovirus does not seem to be spread via drinking water in a country with modern water works.

© 2010 John Wiley & Sons A/S.

[PubMed - indexed for MEDLINE]
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