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Adv Exp Med Biol. 2010;688:165-84.

Gangliosides as regulators of cell membrane organization and functions.

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  • 1Center of Excellence on Neurodegenerative Diseases, Department of Medical Chemistry, University of Milan, Segrate, Italy.

Abstract

Gangliosides, characteristic complex lipids present in the external layer of plasma membranes, deeply influence the organization of the membrane as a whole and the function of specific membrane associated proteins due to lipid-lipid and lipid-protein lateral interaction. Here we discuss the basis for the membrane-organizing potential of gangliosides, examples of ganglioside-regulated membrane protein complexes and the mechanisms for the regulation of ganglioside membrane composition.

PMID:
20919654
[PubMed - indexed for MEDLINE]
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