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Eksp Klin Farmakol. 2010 Aug;73(8):39-42.

[Use of interferon inducers for pharmacological correction of cytokine disturbances in patients with recurrent genital herpes].

[Article in Russian]


The level ofcytokines was studied in the blood of 111 women aged 18 to 56 with recurrent genital herpes caused by herpes simplex virus (HSV) type 1 or 2 (for the frequency of relapses within 6-9 year) treated with interferon inducers iodantipyrin, cycloferon and amixin in combination with basic aciclovir therapy. It is found that, in patients with clinical effect of treatment (decrease in the frequency of relapses) the level of cytokines of nonspecific immune response (alpha-interferon, beta-interferon, tumor necrosis factor-alpha) and Th1 profile gamma-interferon, interleukin-2) increased and the concentrations of interleukin-10 decreased 1.5-3 months after beginning of drug administration. A special feature of drug action for iodantipyrin was a relatively large increase in the blood level of alpha-interferon, for cycloferon--in the level of tumor necrosis factor-alpha, and for amixin--in the level of gamma-interferon. In the absence of any clinical effect, interferon inducers produced only small and brief (in 1.5 months after the beginning of treatment) increase in the blood content of proinflammatory cytokines (alpha-interferon, gamma-interferon, interleukin-2) at a stable high level of interleukin-10.

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