Abstract
Autosomal dominant (early-onset) Alzheimer disease and the much more common sporadic Alzheimer disease share a common pathology but not necessarily a common pathophysiology. Common cardiovascular comorbidities are associated with increased risk for Alzheimer disease and offer opportunities for intervention. Class I evidence for prevention is extremely limited. The overall body of evidence suggests the best time to intervene is in midlife, not in old age.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Alzheimer Disease / epidemiology*
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Alzheimer Disease / genetics
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Alzheimer Disease / physiopathology*
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Alzheimer Disease / prevention & control*
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Amyloid / metabolism
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Cardiovascular Diseases / epidemiology*
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Comorbidity
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Diabetes Mellitus / epidemiology*
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Estrogens / adverse effects
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Humans
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Middle Aged
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Mitochondria
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Models, Theoretical
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Oxidative Stress
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PPAR gamma / agonists
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Plaque, Amyloid
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Risk
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Thiazolidinediones / pharmacology
Substances
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Amyloid
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Estrogens
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PPAR gamma
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Thiazolidinediones