Alzheimer disease prevention: focus on cardiovascular risk, not amyloid?

Cleve Clin J Med. 2010 Oct;77(10):689-704. doi: 10.3949/ccjm.77gr.2010.

Abstract

Autosomal dominant (early-onset) Alzheimer disease and the much more common sporadic Alzheimer disease share a common pathology but not necessarily a common pathophysiology. Common cardiovascular comorbidities are associated with increased risk for Alzheimer disease and offer opportunities for intervention. Class I evidence for prevention is extremely limited. The overall body of evidence suggests the best time to intervene is in midlife, not in old age.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / epidemiology*
  • Alzheimer Disease / genetics
  • Alzheimer Disease / physiopathology*
  • Alzheimer Disease / prevention & control*
  • Amyloid / metabolism
  • Cardiovascular Diseases / epidemiology*
  • Comorbidity
  • Diabetes Mellitus / epidemiology*
  • Estrogens / adverse effects
  • Humans
  • Middle Aged
  • Mitochondria
  • Models, Theoretical
  • Oxidative Stress
  • PPAR gamma / agonists
  • Plaque, Amyloid
  • Risk
  • Thiazolidinediones / pharmacology

Substances

  • Amyloid
  • Estrogens
  • PPAR gamma
  • Thiazolidinediones